Effects of a guided neck-specific exercise therapy on recovery after a whiplash: A systematic review and meta-analysis.

OBJECTIVE: To analyze the effects on pain and disability recovery after a whiplash of a guided neck-specific exercise (NSE) therapy, compared to a different or an unguided NSE therapy. DESIGN: A literature search was conducted from inception to May 31, 2023, in three electronic databases: PubMed, ScienceDirect, and Web of Science. Eleven randomized controlled trials were included. Meta-analyses were performed with Review Manager software. The standardized mean difference (SMD) with a 95% confidence interval (CI) was used to measure the effect sizes and only short-term time points were considered. RESULTS: Not all studies reported a significant decrease of pain and disability in the NSE group compared to controls. However, meta-analyses demonstrated a significantly greater decrease in neck pain (SMD: -0.25; 95% CI: [-0.38, -0.12]; p = 0.0002) and neck-disability index (SMD: -0.35; 95% CI: [-0.54, -0.15]; p = 0.0005) in the NSE group. CONCLUSION: In addition to the benefits that a guided NSE therapy has on motivation and program adherence, it provides greater benefits in pain and disability than a different or unguided NSE therapy. Positive results are observed primarily with intervention periods of more than six weeks and at least two sessions per week.

A Late Antiquity case of a chronic osteomyelitis from the population of Cortijo Coracho, Córdoba, Spain (IV-VIII centuries AD).

The Cortijo Coracho archaeological site dates from the Late Antiquity period, from the 5th to the 8th century AD. During this period, a number of populations settled in the area (Germanic peoples until Visigothic rule, Byzantine until the arrival of the Arabs, etc.), each of them concentrating the historical characteristics in the Sub-Baetic that are currently known. The Cortijo Coracho archaeological site is currently located in the city of Lucena (Cordoba, Spain), found after the works on the A-45 motorway. The necropolis consists of 294 inhumations and the remains of a basilica, although after a series of surveys it is estimated that there are around 700 additional burials, which would make it the largest necropolis with ad sancti burials surrounding a martyrial basilica dating back to the 4th century AD. Among the burials, 397 subjects were recovered, which implies a large presence of shared and/or reused burials. These subjects were transferred to the city's museum, where they were examined, reorganised and classified. At this point, subjects of scientific interest were found, as is the case of subject 204, the topic of this article. This individual, described as an adult male, is an example of the living conditions of this period, since despite his injury on the left lower extremity, a double fracture aggravated by a chronic osteomyelitis infection, he continued to use that limb. This paper will give the details of that distinctive lesion and the possible hypotheses underlying it.

Development and validation of new bioelectrical impedance equations to accurately estimate fat mass percentage in a heterogeneous Caucasian population.

Fat mass percentage (%FM) is frequently determined by nutritionists and personal trainers with bioelectrical impedance analysis (BIA) devices. The aims of the present study were: (1) to develop new regression equations using dual-energy X-ray absorptiometry (DXA) as the reference method for estimating %FM in a heterogeneous Caucasian population with a foot-to-hand device (BIA-101) and a hand-to-hand device (BIA-TELELAB) and (2) to compare the new equations with the manufacturers' equations. We hypothesized that the new equations would lead to more accurate estimations compared with DXA. A total of 218 healthy Caucasian participants aged 18 to 65 years were divided into a development group and a validation group. The accuracy of the different equations was assessed by mean differences, coefficient of determination, standard error of the estimate (SEE), intraclass correlation coefficients (ICC), and Bland-Altman plots. The proposed equation for BIA-101 explained 90.0% of the variance in the DXA-derived %FM, with a low random error (SEE = 2.98%), excellent agreement (ICC = 0.94), no fixed bias, and relatively low individual variability (5.86%). For BIA-TELELAB, the proposed equation explained 88.0% of the variance in the DXA-derived %FM, with a low random error (SEE = 3.27%), excellent agreement (ICC = 0.93), no fixed bias, and relatively low individual variability (6.37%). The results obtained for the manufacturers' equations confirm that these equations are not a good option for %FM assessment. As hypothesized, the new regression equations for BIA-101 and BIA-TELELAB devices can accurately estimate %FM in a heterogeneous Caucasian population with a broad age range.

Magnetic coagulometry: towards a new nanotechnological tool for ex vivo monitoring coagulation in human whole blood.

Blood clotting disorders consisting of unwanted blood clot formation or excessive bleeding are some of the main causes of death worldwide. However, there are significant limitations in the current methods used to clinically monitor the dynamics of clot formation in human whole blood ex vivo. Here a new magnetic coagulometry platform for testing ex vivo coagulation is described. This platform exploits the sensitivity of the out-of-phase component of alternating current (AC) magnetic susceptibility (χ'') to variations in mobility and agglomeration of magnetic nanoparticles when trapped during blood clot formation. By labelling human whole blood with magnetic nanoparticles, the out-of-phase component of AC magnetic susceptibility shows that the dynamics of blood clot formation correlates with a decrease in the out-of-phase component χ'' over time activation of coagulation. This is caused by a rapid immobilisation of nanoparticles upon blood coagulation and compaction. In contrast, this rapid fall in the out-of-phase component χ'' is significantly slowed down when blood is pre-treated with three different anticoagulant drugs. Remarkably, the system showed sensitivity towards the effect of clinically used direct oral anticoagulation (DOAC) drugs in whole blood coagulation, in contrast to the inability of clinical routine tests prothrombin time (PT) and partial thromboplastin time (PTT) to efficiently monitor this effect. Translation of this nanomagnetic approach into clinic can provide a superior method for monitoring blood coagulation and improve the efficiency of the current diagnostic techniques.

Cultural Adaptation, Validation and Evaluation of the Psychometric Properties of an Obstetric Violence Scale in the Spanish Context.

Obstetric violence refers to dehumanized or derogative treatment of women in their pregnancy, childbirth or postpartum periods and may be manifested in different ways. Currently, there is no tool validated in Spain to measure women's perception of obstetric violence. The objective of this study was to carry out the cultural adaptation and validation of an existing 14-item obstetric violence scale in the Spanish context and to evaluate its psychometric properties. The research was conducted in two phases: first, a methodological study designed to evaluate content validity, through assessments by eight experts (calculating the Aiken V coefficient) and face validity in a sample of 20 women; second, a cross-sectional study to evaluate construct validity (through confirmatory factor analysis and Rasch analysis), divergent validity against a scale of birth satisfaction, known-groups validity and, finally, reliability. In Phase 1, Aiken V values higher than 0.71 were obtained for all items. Phase 2 was conducted on a sample of 256 women and the fit values for the unidimensional model were RMSEA: 0.070 (95% CI: 0.059-0.105) and GFI: 0.982 (95% CI: 0.823-0.990). The Rasch analysis indicated poor performance of item 2, which was removed. The Omega and Cronbach's Alpha coefficients were 0.863 and 0.860, respectively. A final 13-item version of the Obstetric Violence Scale was produced, with a total score ranging from 0 (no obstetric violence perception) to 52 (maximum obstetric violence perception). The Obstetric Violence Scale is a reliable and useful tool to measure women's perception of obstetric violence. This study was not registered.

Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials.

Quercetin (Q) is one of the most frequently consumed flavonoids in the human diet. The purpose of this systematic review and meta-analysis was to determine the effects of Q supplementation on muscle damage, muscle soreness and biochemical markers of inflammation, antioxidant capacity and oxidative stress after intense exercise. A literature search of SPORTDiscus, PubMed, Web of Science and Scopus was performed from inception to May 31, 2022. Forest plots were generated with fixed or random-effect models and standardized mean differences (SMD). Data extraction and quality assessment were performed independently by two authors. After application of the inclusion and exclusion criteria, 13 studies with a total of 249 sedentary to well-trained participants were included. For all studies there were some concerns about the risk of bias. All but one study used a supplementation dosage of 1000 mg/day. Q supplementation accelerated recovery of muscle function and significantly decreased muscle soreness 0/24 h after exercise (SMD: -1.33; p = 0.03), creatine kinase levels 24/48 h after exercise (SMD: -1.15; p = 0.02), and post-exercise oxidative stress (SMD: -0.92; p = 0.03). However, Q supplementation had no effect on IL-6 concentration. Q supplementation with a dose of 1000 mg/day for periods of more than seven days and a maximum of 12 weeks appears to be a safe and efficacious strategy to reduce muscle damage and muscle soreness, as well as to enhance recovery after intense exercise in sedentary to well-trained young men. Systematic review registration: PROSPERO CRD42021266801.

Estimating the heating of complex nanoparticle aggregates for magnetic hyperthermia.

Understanding and predicting the heat released by magnetic nanoparticles is central to magnetic hyperthermia treatment planning. In most cases, nanoparticles form aggregates when injected in living tissues, thereby altering their response to the applied alternating magnetic field and preventing the accurate prediction of the released heat. We performed a computational analysis to investigate the heat released by nanoparticle aggregates featuring different sizes and fractal geometry factors. By digitally mirroring aggregates seen in biological tissues, we found that the average heat released per particle stabilizes starting from moderately small aggregates, thereby facilitating making estimates for their larger counterparts. Additionally, we studied the heating performance of particle aggregates over a wide range of fractal parameters. We compared this result with the heat released by non-interacting nanoparticles to quantify the reduction of heating power after being instilled into tissues. This set of results can be used to estimate the expected heating in vivo based on the experimentally determined nanoparticle properties.

Effects of vitamin D supplementation on muscle function and recovery after exercise-induced muscle damage: A systematic review.

BACKGROUND: Vitamin D is essential for the optimal health of the skeletal system. However, this vitamin is also involved in other functions of the human body, such as muscle, immune and inflammatory ones. Some studies suggest that adequate levels of vitamin D support muscular function during exercise and accelerate recovery because they reduce specific pro-inflammatory cytokine levels, but those results have not always been observed. Therefore, this review aims to evaluate the effects of vitamin D supplementation on inflammation, oxidative stress and recovery after exercise. METHODS: This systematic review was conducted using the Preferred Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A literature search of SPORTDiscuss, PubMed, Web of Science and Scopus was performed from inception through February 2022. The articles' methodological quality was assessed with the PEDro scale. RESULTS: After the application of the inclusion and exclusion criteria, 11 eligible articles were included. All the studies were considered of moderate methodological quality. Ten studies involved regular vitamin D supplementation for more than 7 days, and one study performed acute vitamin D supplementation 24 h before exercise. CONCLUSIONS: The existing evidence suggests that vitamin D supplementation for periods of more than 1 week with a minimum dose of 2000 IU/day appears to be an efficacious strategy for attenuating muscle damage and inflammation after exercise. The potential positive effects on muscle function, muscle pain and oxidative stress need to be confirmed with new investigations. Further research is also required to determine the adequate vitamin D dosage to obtain positive effects without adverse effects.

Body Composition, Somatotype and Raw Bioelectrical Impedance Parameters of Adolescent Elite Tennis Players: Age and Sex Differences.

Studies analyzing tennis players' body composition and morphological and bioelectrical characteristics are scarce, especially among adolescents. This study aimed to explore sex- and age-based differences in body composition, somatotype, and bioelectrical properties among elite young male and female tennis players aged 13-16 years. Twenty-two male (14.45 ± 1.10 years) and 20 female (14.30 ± 1.03 years) elite tennis players participated in this study and were compared according to sex (males vs. females) and, within each sex, according to age (13-14 years vs. 15-16 years). Female adolescent elite tennis players had higher body fat (BF) percentage and higher endomorphy than males. They also had lower skeletal muscle mass and total body water (TBW) percentages. Older boys had lower resistance and a higher TBW and phase angle (PhA) than younger boys, likely due to maturation and performance. No significant differences were found between younger and older girls, except for the PhA, potentially associated with better cell function and performance. This study provides valuable reference data for coaches of elite youth tennis players. Due to the few differences found in body composition and somatotype in the different age groups, the PhA may be used by practitioners as a reference for cell function and performance.

Microwave-assisted NixFe1-x nanoclusters ultra-stable to oxidation in aqueous media.

Metal alloy nanoparticles, and, in particular, permalloy, still hold an untapped potential in nanotechnology, although their poor stability against oxidation due to environmental exposure limits their use in many technological applications, and even more in life sciences. We propose a scalable single-step microwave-assisted method to produce water suspensions of Ni1-xFex nanoparticles without the need for an inert atmosphere, either organic solvents or any type of post-processing. We use hydrazine as a reducer, iron(II), iron(III) and nickel(II) chloride as precursors, 1,12-dodecanediol as a surfactant and water as a reaction medium. The mixture is heated at 160 °C for 10 minutes to obtain uniform alloy nanoparticles with sizes of around 24.5 nm for Ni (0% Fe) and 5.5 nm for 35% Fe that are forming uniform aggregates with sizes between 200 nm for Ni and 65 nm for iron oxide NPs. A linear increase of saturation magnetization is observed with an Fe content of up to 25%, whereas for larger percentages a sudden drop takes place due to the formation of iron oxides. X-ray diffraction measurements rule out the formation of any oxides after more than one year of storage at 4 °C, surely due to the presence of 1,12-dodecanediol at the surface, as evidenced by infrared spectroscopy.

The lure of novel biological and chemical entities in food-system transformations.

Synthetic chemicals and biologically engineered materials are major forces in today's food systems, but they are also major drivers of the global environmental changes and health challenges that characterize the Anthropocene. To address these challenges, we will need to increase assessment activity, promote alternative production practices with less reliance on such technologies, and regulate social campaigns and experiments.

Insights into Environmental Drivers on the Reproductive Cycle of Diopatra neapolitana (Polychaeta: Onuphidae).

The reproductive cycle of Diopatra neapolitana was studied over two years in Redondela (NW Spain), considering both the monthly evolution of the percentage of individuals with oocytes and the variation of the mean oocyte size. Moreover, since three other species of Diopatra have recently been documented in regions geographically close to NW Spain, we first confirmed the identity of this species by carrying out a morphological identification of a representative number of the specimens collected. Our data showed a discontinuous reproductive season, with a period of proliferation and maturation of oocytes from January to September and asynchronous spawning events between July and October. Then, a resting period in the months of November and December was observed. We also explored the influence of some relevant environmental factors (namely, water temperature, photoperiod, salinity, primary production and upwelling index) on the observed reproductive cycle. The results suggest that water temperature is one of the most important drivers of the reproductive cycle for this species. Particularly, in Ría de Vigo, the reproductive cycle seems to be influenced by upwelling events of deep cold water that occur frequently between March and September, and that could act as a spawning-inducing switch.

Heating of metallic biliary stents during magnetic hyperthermia of patients with pancreatic ductal adenocarcinoma: an in silico study.

OBJECTIVE: To investigate the eddy current heating that occurs in metallic biliary stents during magnetic hyperthermia treatments and to assess whether these implants should continue to be an exclusion criterion for potential patients. METHODS: Computer simulations were run on stent heating during the hyperthermia treatment of local pancreatic tumors (5-15 mT fields at 300 kHz for 30 min), considering factors such as wire diameter, type of stent alloy, and field orientation. Maxwell's equations were solved numerically in a bile duct model, including the secondary field produced by the stents. The heat exchange problem was solved through a modified version of the Pennes' bioheat equation assuming a temperature dependency of blood perfusion and metabolic heat. RESULTS: The choice of alloy has a large impact on the stent heating, preferring those having a lower electrical conductivity. Only for low field intensities (5 mT) and for some of the bile duct tissue layers the produced heating can be considered safe. The orientation of the applied field with respect to the stent wires can give rise to the onset of regions with different heating levels depending on the shape that the stent has finally adopted according to the body's posture. Bile helps to partially dissipate the heat that is generated in the lumen of the bile duct, but not at a sufficient rate. CONCLUSION: The safety of patients with pancreatic cancer wearing metallic biliary stents during magnetic hyperthermia treatments cannot be fully assured under the most common treatment parameters.

Two Methods of AuNPs Synthesis Induce Differential Vascular Effects. The Role of the Endothelial Glycocalyx.

AuNPs are synthesized through several methods to tune their physicochemical properties. Although AuNPs are considered biocompatible, a change in morphology or properties can modify their biological impact. In this work, AuNPs (~12 to 16 nm) capping with either sodium citrate (CA) or gallic acid (GA) were evaluated in a rat aorta ex vivo model, which endothelial inner layer surface is formed by glycocalyx (hyaluronic acid, HA, as the main component), promoting vascular processes, most of them dependent on nitric oxide (NO) production. Results showed that contractile effects were more evident with AuNPsCA, while dilator effects predominated with AuNPsGA. Furthermore, treatments with AuNPsCA and AuNPsGA in the presence or absence of glycocalyx changed the NO levels, differently. This work contributes to understanding the biological effects of AuNPs with different capping agents, as well as the key role that of HA in the vascular effects induced by AuNPs in potential biomedical applications.

A novel family of non-secreted tridecaptin lipopeptide produced by Paenibacillus elgii.

Bacteria from the genus Paenibacillus make a variety of antimicrobial compounds, including lipopeptides produced by a non-ribosomal synthesis mechanism (NRPS). In the present study, we show the genomic and phenotypical characterization of Paenibacillus elgii AC13 which makes three groups of small molecules: the antimicrobial pelgipeptins and two other families of peptides that have not been described in P. elgii. A family of lipopeptides with [M + H]+ 1664, 1678, 1702, and 1717 m/z was purified from the culture cell fraction. Partial characterization revealed that they are similar to tridecaptin from P. terrae. However, they present amino acid chain modifications in positions 3, 7, and 10. These new variants were named tridecaptin G1, G2, G3, and G4. Furthermore, a gene cluster was identified in P. elgii AC13 genome, revealing high similarity to the tridecaptin-NRPS gene cluster from P. terrae. Tridecaptin G1 and G2 showed in vitro antimicrobial activity against Escherichia coli, Klebsiella pneumonia (including a multidrug-resistant strain), Staphylococcus aureus, and Candida albicans. Tri G3 did not show antimicrobial activity against S. aureus and C. albicans at all tested concentrations. An intriguing feature of this family of lipopeptides is that it was only observed in the cell fraction of the P. elgii AC13 culture, which could be a result of the amino acid sequence modifications presented in these variants.

A comparative analysis of four dental pathologies of the historical population of Cortijo Coracho, Roman southern Spain (4th-8th centuries AD).

Here we present the dental pathologies found in the population of Cortijo Coracho, which dates from Late Antiquity (4th-8th centuries AD) and is located in the region of Lucena (Córdoba). Using a sample of 160 individuals over the age of twenty years at death, with a total of 1681 dental crowns, the frequency of various oral diseases (dental calculus, alveolar reabsorptions, periodontal diseases, and dental abscesses) were analysed. The frequency of oral disease was compared between the mandible and the maxilla, the anterior and posterior teeth as well as the right and left sides. Consideration was given to ante-mortem tooth loss, which may be caused by dental disease. Statistical analysis showed a significantly greater frequency of oral disease in the posterior teeth of the mandible.

Usefulness of ventricular sense response in last-generation cardiac resynchronization therapy devices.

OBJECTIVES: High percentages of pacing were associated to maximal symptomatic and mortality benefit from cardiac resynchronization therapy (CRT). Loss of CRT pacing is linked to intrinsic ventricular activation preceding biventricular pacing (BiV), as it occurs in patients with atrial fibrillation (AF). Last generation CRT devices incorporate the ventricular sense response (VSR) mechanism to maintain biventricular pacing in patients with atrial arrhythmias. This work aimed to characterize electrical dyssynchrony differences among baseline, BiV and VSR pacing, and determine whether the VSR mode is as beneficial as the BiV mode in terms of electrical dyssynchrony. METHODS: Thirty-two patients implanted with CRT devices were retrospectively studied. All patients presented non-ischemic dilated myocardiopathy and complete left bundle branch block (LBBB). Every patient went through baseline, BiV and VSR pacing while recording the 12­lead ECG. Electrical dyssynchrony was assessed by a dyssynchrony index (DIn) obtained from correlation analysis on the 12­lead ECG. RESULTS: When comparing with baseline, VSR pacing improved QRS duration (178 ± 22 ms vs 158 ± 43 ms, baseline vs VSR, p < 0.05) and so did BiV pacing (178 ± 22 ms vs 142 ± 20 ms, baseline vs BiV, p < 0.05). However, electrical dyssynchrony only improved at BiV pacing (2.86±0.6 vs 0.54±0.8, baseline vs BiV, p < 0.05) while VSR showed average DIn values similar to those at baseline. CONCLUSIONS: VSR pacing did not improve the electrical synchrony while did shorten QRS duration in this sample population. Therefore, VSR paced beats would fall in the category of inefficient BiV and may not be the preferred alternative in patients with CRT and AF.

Kinetics and Vertical Stiffness of Female Volleyball Players: Effect of Low-Intensity Plyometric Training.

Purpose: The purpose of this study was threefold: 1) to assess kinematic/kinetic variables and vertical stiffness of recreational young female volleyball players during a vertical jump, 2) to identify the changes in those variables that occurred after low-intensity plyometric training, 3) to determine the relationship between stiffness and performance. Method: Twenty-eight female volleyball players aged 14-18 years were randomly allocated to plyometric group and control group. All participants performed a countermovement jump (CMJ) 3 days prior to and 3 days after the 7-week plyometric training and kinematic and kinetic variables, along with vertical stiffness, were measured. Results: Jump height, average force, average power, peak power and absolute vertical stiffness significantly increased in plyometric group (p < .01). Propulsion impulse and normalized vertical stiffness also increased (p < .05). Maximum displacement of the center of mass significantly decreased in plyometric group (p < .01). Changes in vertical stiffness after the plyometric training showed very strong significant correlations with changes in average force (r = 0.818, p < .01), average power (r = 0.784, p < .01), maximum displacement of the center of mass (r = -0.850, p < .01) and propulsion duration (r = -0.781, p < .01). Conclusion: The 7-week low-intensity plyometric training produced changes in most kinematic and kinetic variables improving CMJ performance. The increase in vertical stiffness after plyometric training may not directly enhance jump performance but it makes the jump quicker increasing the probability of success in volleyball games.

Effects of Beetroot Supplementation on Recovery After Exercise-Induced Muscle Damage: A Systematic Review.

CONTEXT: Beetroots have antioxidant and anti-inflammatory properties, which may help attenuate inflammation and oxidative stress, enhancing recovery from exercise-induced muscle damage (EIMD). OBJECTIVE: To evaluate the effects of beetroot supplementation on oxidative stress, inflammation, and recovery after EIMD. DATA SOURCES: SPORTDiscus, PubMed, Web of Science, and Scopus databases were searched, and hand-searching was performed by looking to relevant studies that were cited in other studies. STUDY SELECTION: For a study to be included in this review, the following inclusion criteria had to be met: (1) research conducted with human participants, (2) original articles in peer-reviewed publications, (3) original studies that had investigated beetroot supplementation intervention on muscle damage and recovery, (4) research conducted with 1 control/placebo group, and (5) articles published from inception to October 2020. STUDY DESIGN: Systematic review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. LEVEL OF EVIDENCE: Level 3. DATA EXTRACTION: Two of the 4 authors independently extracted data and assessed the methodological quality of the articles with the PEDro scale. All discrepancies were resolved through a consensus meeting. RESULTS: A total of 9 studies were included in this review. The methodological quality of the included studies ranged from moderate to high. Most of the studies found a better recovery of functional variables and muscle soreness, but improvements in markers of muscle damage, inflammation, and oxidative stress were not reported. CONCLUSION: The existing evidence suggests that a short-term beetroot supplementation has the potential to accelerate recovery of functional measures and muscle soreness, but further research is needed to clarify if a longer supplementation period (with some days before exercise and some days after) could also promote recovery of markers of muscle damage, inflammation, and oxidative stress.

Privacidad y confidencialidad de los datos genéticos y genómicos de uso diagnóstico en Colombia. Legislación comparada con Australia / Privacy and Confidentiality of Genetic and Genomic Data for Diagnostic Use in Colombia. Legislation Compared to Australia / Privacidade e confidencialidade de dados genéticos e genômicos para uso diagnóstico na Colômbia. Legislação em comparação com a Austrália

Resumen: La información genética y genómica requiere regulaciones estrictas para su manejo adecuado con el fin de evitar la divulgación inapropiada y la discriminación secundaria, pues tiene una relación directa con los derechos fundamentales y los principios bioéticos. De ahí la necesidad de evaluar la regulación colombiana existente, por lo que se realizó una revisión sistemática de la literatura en bases de datos del 2000 al 2020, sitios web del Congreso de la República de Colombia, la Comisión de Reforma de la Ley Australiana y la Corte Constitucional de Colombia, para identificar las falencias y los aciertos en la jurisprudencia actual del manejo, el control y la accesibilidad de la población colombiana a las pruebas e información genética. Se toma como referente Australia para comprender y plantear mejoras. Se encontró que en Colombia la información genética se cataloga como sensible (Sentencia C-334-10) con regulaciones inespecíficas sin norma legislativa. En contraste, Australia dispone de directrices bioéticas específicas, penalización y protocolos que abarcan las implicaciones individuales y colectivas descritas en el Privacy Legislation Amendment Act del 2006. Es necesario que en Colombia se cree una regulación jurídica específica para la información genética y genómica con énfasis en pautas de uso sobre la privacidad, la divulgación y la no discriminación.

Abstract: Genetic and genomic information requires strict regulations for its proper handling in order to avoid inappropriate disclosure and secondary discrimination, since it is directly related to fundamental rights and bioethical principles. Hence the need to evaluate the existing Colombian regulation, for which a systematic review of the literature was carried out on databases from 2000 to 2020, websites of the Congress of the Republic of Colombia, the Australian Law Reform Commission and the Constitutional Court of Colombia, to identify the shortcomings and the successes in the current jurisprudence of the management, control and accessibility of the Colombian population to tests and genetic information. Australia is taken as a reference to understand and propose improvements. It was found that in Colombia genetic information is classified as sensitive (Sentence C-334-10) with non-specific regulations without legislative norm. In contrast, Australia has specific bioethical guidelines, criminalization and protocols that cover the individual and collective implications described in the Privacy Legislation Amendment Act of 2006. It is necessary that a specific legal regulation be created for genetic and genomic information with emphasis on usage guidelines on privacy, disclosure and non-discrimination in Colombia.

Resumo: As informações genéticas e genômicas requerem regulamentações rígidas para o seu correto manuseio, a fim de evitar a divulgação inadequada e a discriminação secundária, pois está diretamente relacionada aos direitos fundamentais e aos princípios bioéticos. Daí a necessidade de avaliar a regulamentação colombiana existente, para a qual foi realizada uma revisão sistemática da literatura em bancos de dados de 2000 a 2020, sites do Congresso da República da Colômbia, da Comissão Australiana de Reforma da Lei e do Tribunal Constitucional da Colômbia, identificar as deficiências e os sucessos na jurisprudência atual da gestão, controle e acessibilidade da população colombiana a testes e informação genética. A Austrália é tomada como referência para entender e propor melhorias. Constatou-se que na Colômbia a informação genética é classificada como sensível (Sentença C-334-10) com regulamentações não específicas sem norma legislativa. Por outro lado, a Austrália possui diretrizes bioéticas específicas, criminalização e protocolos que abrangem as implicações individuais e coletivas descritas na Lei de Emenda à Legislação de Privacidade de 2006. É necessário que na Colômbia seja criada uma regulamentação legal específica para informações genéticas e genômicas com ênfase no uso diretrizes sobre privacidade, divulgação e não discriminação.